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These macrophages exist in three different subtypes (M2a, M2b, and M2c) according to different activation stimuli and exert a protective function through secretion of IL-10 and TGF- which suppress effector T lymphocytes and activate Tregs [113,114,115]

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519 The activation of this pathway enhances cell proliferation and metastatic capabilities by promoting epithelial-mesenchymal transition (EMT), thereby increasing the invasiveness and metastatic potential of tumors

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Growth Hormone and Treatment Controversy

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doi: 10.1007/s12033-007-0045-x

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