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At first, we found that addition of an end-repair step to fill in 5 overhangs and detect base-editor-modified gDNA resulted in high background and detection of only a small fraction (20%) of previously validated off-target sites (Extended Data Fig
In addition, genes upregulated by smoking among apical epithelial cell types ( KRT8 high , mucus secretory, and ciliated) were enriched for mucus secretory cell markers, supporting an increase in the secretory activity of these cells (Fig
Golden Tobacco Limited Golden Tobacco Limited, established in 1930 and headquartered in Mumbai, is a diversified tobacco company with a strong presence across the cigarette, bidi, and chewing tobacco segments
The perception of harm of e-cigarettes and cigarettes was assessed by asking separate questions using the following stem: How much do you think people harm themselves when they smoke cigarettes/use e-cigarettes?, with response options of no harm, little, some, or much harm
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