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Animal doses cannot be directly extrapolated to humans Key Research Findings# Selective and membrane-permeable small molecule inhibitors of nicotinamide N-methyltransferase reverse high fat diet-induced obesity in mice , published in Biochemical Pharmacology (Neelakantan H et al., 2018

KPV increases blood flow by activating endothelial nitric oxide synthase (eNOS), which increases the generation of nitric oxide, a potent vasodilator that relaxes blood vessels and reduces blood pressure

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