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On the contrary, GLP-1 RAs may confer protective effects against colorectal and liver cancers, likely due to their weight loss and anti-inflammatory properties

Response rates vary by molecule newer agents such as tirzepatide and semaglutide yield higher responder rates (~86%91%) than older agents such as exenatide or liraglutide (~40%65%) (223) and vary by baseline BMI, sex, and glycemic status, with women and individuals with higher BMI responding better (222, 224)

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39 Incretins not only enhance neuronal glucose utilization and mitochondrial efficiency but also attenuate the proinflammatory milieu that perpetuates chronic glial activation