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The most frequently reported side effect is water retention, which actually contributes to creatine's muscle-building benefits

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He hypothesized that lactic acidosis, increased concentration of Krebs cycle metabolites in urine, reduced levels of carnitine in plasma, decreased utilization of glucose in the brain, and lowered ATP levels in these patients are associated with mitochondrial dysfunction [66]

Why does OxyR induce glutaredoxin 1 and thioredoxin 2