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Nevertheless, human studies suggest that neurons can be formed in the striatum, a structure that plays an important role in cognition and motor function and is close to the SVZ ( FIGURE 1 The Hippocampal Neurogenic Niche The second major neurogenic niche in the adult brain is the SGZ of the hippocampal dentate gyrus, where adult born granule cells (abGCs) are produced, mature and integrate into the existing network (Figures 1A,D,E

Convection-enhanced delivery A local delivery method that directly infuses therapeutic agents in the brain through an implanted catheter that generates a pressure gradient at its tip