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found that epithalon extended the lifespan of rats exposed to natural and constant illumination by reducing the incidence of spontaneous tumors [5]

In the psychiatry clinical setting, VPA is frequently used for several psychiatric disorders as a mood stabilizer and combined with various types of antipsychotics.[1] Adverse reactions to VPA involve neurological, hematopoietic, hepatic, and digestive systems.[2] Among the metabolic disorders, VPA-induced hyperammonemia,[3] which is characterized by lethargy, vomiting, cognitive slowing, focal neurological deficits, and decreasing consciousness ranging from drowsiness to coma, is an important clinical consideration.3 In psychiatric patients, VHE may be difficult to differentiate from the exacerbation of psychiatric symptoms