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SURMOUNT-1 (72-week randomized study, adults without diabetes): tirzepatide produced an average loss of 15.0% (5 mg dose), 19.5% (10 mg dose), and 20.9% (15 mg dose) of body weight, versus 3.1% with placebo, under a similar lifestyle-intervention protocol

The 24% mean weight-loss figure from Phase 2 data approaches the results seen with bariatric surgery, which produces 20 to 35% total body-weight loss depending on the procedure [10]

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