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Third, both studies support a division of labor among E2s: Ube2e2 family members are not sufficient to drive substrate ubiquitination with COP1 alone, whereas Ube2d3/UbcH5 enzymes support chain building within CRL4 DET1-COP1 assemblies

This is because generalizing the findings to different populations or explaining rare conditions is a serious challenge

Renal macrophages monitor and remove particles from urine to prevent tubule obstruction