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Additionally, the cyclic trisulfide structure of LASSS, as opposed to the linear trisulfides such as GSSSG and cysteine trisulfide (Cys-SSS-Cys), could guarantee the unique reactivity of LASSS (see again Figure 1a for chemical structures)

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This CNS mechanism is distinct from GLP-1 receptor-mediated appetite suppression and represents an additional pathway through which cagrilintide may reduce caloric intake in research models