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In clinical studies, higher levels of circulating long- and medium-chain acylcarnitines showed mixed results in patients with Alzheimers disease [24, 25] whereas clinical trials of patients with Parkinsons disease have consistently shown that circulating levels of long-chain acylcarnitines are decreased [26,27,28]

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By the 1970s, one hormone was identified as an incretin candidate: Gastric Inhibitory Polypeptide (GIP) , discovered in 196970, which was found to stimulate insulin secretion (and renamed Glucose-Dependent Insulinotropic Polypeptide ) ( [30] )