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doi: 10.1111/j.1527-3466.2006.00077.x [DOI] [PubMed] [Google Scholar] 4.Alloubani A, Saleh A, Abdelhafiz I

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PCOS is a heterogeneous disease characterized by hyperandrogenism, dysfunctional ovulation, and polycystic ovary morphology, accompanied by metabolic abnormalities, such as insulin resistance (IR) and obesity

The same goes for liver issues no formal dose adjustments are needed, but well monitor you more carefully