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While hyperinsulinemia increases TC malignancy, metformin, an oral hypoglycemic drug, is verified to impede glycolysis and promote TCA cycle via downregulating LDHA and PKM2 and enhancing IDH1 expression [265, 266]

Link to Study Resources: Sikiric, P., Seiwerth, S., & Cesarec, V

The degree of melanin pigmentation is determined by the number and distribution of melanocytes in the basal cell layer of the oral epithelium of each anatomical region, by their melanogenic activity, by the degree of arborisation of the dendritic processes of the melanocytes, and by the number, size, and distribution of melanosomes in the melanocyte-keratinocyte unit [46]

doi: 10.1182/blood-2008-03-040253