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The injectable formulations are administered once weekly via subcutaneous injection, meaning the medication is delivered into the fatty tissue layer beneath the skin rather than into muscle or directly into the bloodstream
Blood pressure reduction, nephron remodeling, reduction in arterial stiffness, are all well-known mechanisms associated with the CV benefits observed with the use of SGLT2i [21] but they are not sufficient to fully explain the metabolic effects
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In a controlled crossover feeding study, a high-GI meal selectively increased activation in reward and craving regions four hours postprandially compared with an isocaloric low-GI meal, independent of palatability [26]
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