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For parents of adolescent and young adult males, understanding the distinction between these substancesand recognizing the serious health implications of bothhas never been more critical

Studies of this phenomenon have shown that macrophages are activated by factors such as cigarette smoke extracts and release inflammatory mediators such as TNF-, CXCL1, CXCL8, CCL2, leukotriene (LT) B4 and reactive oxygen species (ROS), etc., which mediate the inflammatory response ( Figure 2 Macrophages have different phenotypes with different activation pathways that lead to different organismal responses

doi: 10.1016/s1470-2045(22)00540-x 21