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These changes are mediated through the ERK1/2-eIF4E signaling pathway, which in turn has an impact on learning and memory processes

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We focus on delineating how this integrated approach moves beyond the limitations of conventional monotherapy, explore the emerging evidence supporting its clinical application, and identify key questions that must be addressed to advance its role in modern, precision-oriented UC management

These costs represent significant barriers for many individuals, highlighting the importance of evidence-based protocols that maximize benefit