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The newly synthesized dopamine is then rapidly transported into presynaptic vesicles by VMAT2, secreted after nicotine stimulation and rapidly recycled by DAT and VMAT into presynaptic vesicles, leading to a net increase in dopamine content 53
Because many of the datasets included UK Biobank participants, who are more educated, lead healthier lifestyles, and have fewer health problems than the UK population 53 , this discrepancy may limit the applicability of our findings to other populations
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