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KPV is attractive to researchers because it seems to target important inflammatory pathways without producing the broad immune suppression observed with many drugs

In patients with IBD, it is usually described a reduced bacterial diversity, with a decreased relative abundance of Firmicutes and an increase in pro-inflammatory bacteria, such as Proteobacteria, or adherent-invasive Escherichia coli or mucolytic bacteria such as Ruminococcus gnavus and Ruminococcus torques [37]

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