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Chronic inflammation increases the risk of colorectal cancer, necessitating regular surveillance colonoscopy, typically beginning 8 years after disease onset for extensive colitis, with intervals of 1-3 years based on individual risk factors

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N Engl J Med 2023;389:222132.ArticlePubMed 73

The glutamase inhibitor telaglenastat (CB-839) if combined with other therapeutic interventions has shown promise in initial clinical trials with an acceptable safety profile and some reduction in tumor progression (95, 96)