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We also observed that in these two trials, a small number of patients (5 of 3297 in SUSTAIN 6 & 3 of 3183 in PIONEER 6) were using SGLT-2i at baseline, suggesting that combined use of these two kinds of drugs may exist in these studies

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This puts them at increased risk of death and many serious health issues, but losing weight and keeping it off through diet changes and exercise the standard approach is notoriously difficult

Using a GRADE framework, the certainty of evidence for global IBS symptom improvement is considered low to very low because of imprecision, risk of bias, and inconsistency across trials