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The mRNA levels of inflammatory factors ( Tnf-, Il-1, NLRP3 , and Tlr2 ) were also significantly increased in the constipated mice, and WECSL treatment inhibited this upregulation (Figure 3B)

Second, it is noteworthy that there was significant heterogeneity in patients with low cardiovascular disease risk (defined as those without severe cardiovascular diseases) across the included studies