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Interestingly, bone loss was observed in 12-week-old male BALB/c mice after broad-spectrum antibiotics (ABX) treatment for 2 weeks (46), and an alcoholic osteoporosis model induced by ethanol has also been established to counteract the skeletal problems in chronic drinkers (47)

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Together, these findings suggest that circadianmenstrual interactions may contribute to variability in metabolic regulation, although direct evidence linking these rhythms to nutrient metabolism remains limited