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Semaglutide 24 mg once a week in adults with overweight or obesity, and type 2 diabetes (STEP 2): a randomised, double-blind, double-dummy, placebo-controlled, phase 3 trial

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This compound is mainly found in the liver and muscles

However, the understanding of the stereochemistry of the MSA-DH reaction is crucial for the elucidation of the overall carnitine degradation pathway: L-malate might be directly channeled into the tricarboxylic acid cycle whereas D-malate would require a specific oxidation step that potentially yields the central metabolite oxaloacetate or pyruvate