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In one study, even supra-pharmacologic bolus doses of GLP-1 provided only transient glucose reductions and often triggered nausea/vomiting (due to high peak levels) ( [42] ) ( [77] )

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64 Even though CVC has a differentiated mechanism of action compared to OCA and Resmetirom, weaker efficacy data compared to both those candidates have reduced confidence in the drugs efficacy as a monotherapy (see Figure 3)