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10.1016/s0006-8993(01)02870-0 222 MancusoR.Del ValleJ.ModolL.MartinezA.Granado-SerranoA
Acta 60 GhibelliL.CoppolaS.FanelliC.RotilioG.CivitarealeP.ScovassiA
In rare cases, repeated injections at the same site can cause tissue irritation or muscle pain
In rodent models of acute ischemic stroke induced by middle cerebral artery occlusion (MCAO), semaglutide treatment resulted in a substantial reduction in the volume of the resultant brain infarct by 48%63% and facilitated improved functional recovery ( 4.4 Metabolic dysfunction and other models Semaglutides capacity to ameliorate cognitive deficits induced by a high-fat diet in murine models underscores its potential to directly mitigate the neurological consequences associated with metabolic disorders ( 4.5 Translational limitations and contradictory evidence Despite substantial neuroprotective evidence observed in numerous animal models, it is imperative to recognize significant translational limitations and some contradictory findings
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