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Lipid metabolism is involved in the process of cartilage synthesis ( 2.2.1 Choline pathway 2.2.1.1 Choline kinasea tried enzyme in RA With the aggravation of inflammation, the choline pathway, where choline kinase (Chok) catalyzes the conversion of choline into CDP-choline and subsequent formation of phosphatidylcholine (PC), is highly activated in FLS, resulting in the activation of the regulatory MAPK/PI3K/Akt pathway, MMP expression, and promotion of invasive metastasis of RAFLS cells (Figure 2) ( FIGURE 2 2.2.1.2 Natural products targeting choline pathway Network pharmacological studies have shown that Tripterygium wilfordii glycosides (TWG) can target PLA2 and thus interfere with glycerophospholipid metabolism and ether lipid metabolism, resulting in changes in lysoPC and PC levels

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