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The muscle loss risk from retatrutide is proportionally higher in people over 60, and the need for structured resistance training is even more critical in this group

Their experts point to enough protein, smaller meals and snacks, hydration, and both aerobic exercise and strength training as ways to support nutrition, preserve lean mass, and manage common symptoms

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Key Differences FDA-Approved Uses The first key difference between the four options is FDA approval: Wegovy: Approved for weight loss (BMI 30 or 27 and a comorbidity) Ozempic: Approved for Type 2 diabetes Rybelsus: Approved for Type 2 diabetes FDA-approved medications may also be prescribed off-label in certain cases