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27, 28 The resulting endothelial dysfunction as one of the first and critical steps in atherogenesis is caused by CSE-induced endothelial cell contraction, 27 the release of pro-inflammatory cytokines, 27 catalalysation of oxidative reactions, 29 the increased expression of adhesion molecules 30 and finally the induction of endothelial cell death (resulting in endothelial denudation)