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10.1016/j.ijwd.2021.07.002 5 BuzdarA.DoumaJ.DavidsonN.ElledgeR.MorganM.SmithR.et al (2001)
The extended persistence of the aza-analogues in circulation confirms that these substitutions slow peptide clearance in vivo
But a study earlier this year found 65% of those without diabetes discontinued the drugs in less than one year, according to a study in JAMA Network Open
Trial Metric Retatrutide 12mg (TRIUMPH-4) Semaglutide 2.4mg (STEP 1) Mean Weight Loss 28.7% at 68 weeks 14.9% at 68 weeks Mechanism Triple agonist (GLP-1/GIP/GCGR) Single agonist (GLP-1) FDA Status Phase 3 (investigational) Approved (Wegovy) Dosing Weekly subcutaneous Weekly subcutaneous Common Adverse Events GI (nausea, vomiting, diarrhea), dysesthesia GI (nausea, vomiting, diarrhea) Important caveat: These results come from different trial populations and study designs
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