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These interconnected axes-Ca dysregulation, mitochondrial collapse, ERS, and NAD crisis form a self-amplifying loop that highlights multi-target therapeutic opportunities for neurodegenerative diseases (Fig

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Symptoms of Graves Disease People with Graves disease may experience one or more of the following symptoms: Common Symptoms Associated with Graves Disease Irregular or rapid heartbeat, palpitations A fine tremor in the hands or fingers Anxiety or irritability Weight loss, despite normal eating habits (or even having an increased appetite) Heat sensitivity, hot flashes or increased perspiration Hair loss Muscle weakness Enlargement of the thyroid gland (goiter) Change in menstrual cycles (typically becoming lighter or irregular) Reduced libido Frequent or loose bowel movements Fatigue , yet difficulty with sleeping Separation of fingernails from the nail bed Increased risk of miscarriage Loss of calcium, leading to decreased bone density over time (Less commonly found) Graves dermopathy (the reddening and thickening of the skin, most often on the shins or the tops of the feet) Here is a visual to help you compare the symptoms of hyperthyroidism with the common symptoms of hypothyroidism