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Good to excellent test-retest reliability was found for the PROMIS SD SF 8b T-score between Weeks 6 and 7, and Weeks 8 and 9 (intra-class correlation coefficients (ICCs) 0.910-0.927)

Clinical Trials: In Phase II and III cachexia studies, subjects received 13 mg/day for up to 12 weeks, resulting in significant increases in lean body mass and improved function Research Context: Other studies tested doses up to 9 mg/day, showing a clear dose-response effect on lean mass accrual

Analysis of labeled BCAAs metabolites showed more labeled -Ketoisocaproate (-KIC) and Leu-derived BCKAs in NSCLC cells