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This triggers downstream signaling pathways (e.g., NF-B and MAPK), driving the massive release of pro-inflammatory cytokines, including IL-1, IL-6, and TNF- (167170)

Massaad CA, Klann E

These enzymes catalyze the conjugation of glutathione with various toxins, including: Pesticide residues Industrial chemicals Alcohol metabolites Prescription drug byproducts Step 3: Sulfation Support Glutathione provides sulfur groups needed for sulfation, another crucial phase II detoxification pathway

many patients are initially asymptomatic, and treatment is typically deferred until iwCLL 2018 criteria are met, with risk stratification guided by the CLL-IPI (including TP53 disruption, IGHV status, -microglobulin, stage, and age) [235]