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K-means clustering analysis of amplicon sequence variants by animal demonstrated that NNMTi-treated DIO mice switched to LD had a distinct microbiome pattern that was highlighted by decreased Erysipelatoclostridium and increased Lactobacillus relative abundances compared to vehicle counterparts

While human clinical trial data remains limited, anecdotal reports from users align remarkably well with the outcomes observed in animal research

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(E) Alterations in the local environment around the PMP in the COOT modified model, suggesting changes that may impact PMP interaction and enzyme function