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Supplementary material The Supplementary Material for this article can be found online at: Abbreviations CKD, chronic kidney disease

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Injection Day 1 served as both the acute test and the first time point in the repeated-treatment timeline allowing evaluation of acute effects without requiring a separate acute-only experiment, minimizing animal use while preserving statistical power

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In reality, methionine sulfoxide is a substance that has been associated with age-related oxidative damage in several occasions

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If you experience a suspected side effect from any medicine or medical device, you can report it directly via the MHRA Yellow Card Scheme at yellowcard.mhra.gov.uk or through the Yellow Card app

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