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Dysregulation of Glutathione Homeostasis in Neurodegenerative Diseases

In November 2023, the FDA granted approval for Zepbound (tirzepatide) for chronic weight management in adults with obesity (body mass index 30 kg/m) or overweight (BMI 27 kg/m) with at least one weight-related comorbid condition such as hypertension, dyslipidemia, type 2 diabetes, obstructive sleep apnea, or cardiovascular disease

Professor Gailer added, Our results show that L-glutathione and L-cysteine, natural biomolecules found inside cells, react with THI under normal conditions found in the human body, reinforcing that the uncovered interactions are likely to happen under normal conditions inside human cells

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