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For type 2 diabetes , NICE guideline NG28 recommends GLP-1 receptor agonists in specific circumstances, including: As part of triple therapy (with metformin and either a sulfonylurea or pioglitazone) when dual therapy with metformin and another oral drug has not achieved adequate glycaemic control As part of triple therapy with metformin and a sodium-glucose cotransporter 2 (SGLT2) inhibitor if certain criteria are met In combination with insulin, with or without other antidiabetic drugs Treatment should be continued only if there is a beneficial metabolic response (reduction of at least 11 mmol/mol in HbA1c and weight loss of at least 3% at 6 months)