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These timelines are supported by Cleveland Clinics guidance on Vitamin C serums, which consistently cites four to twelve weeks as the window for visible brightening results depending on the concentration and consistency of use

10.1016/j.ceb.2010.10.012 [DOI] [PMC free article] [PubMed] [Google Scholar] 71.Ellgaard L, Sevier CS, Bulleid NJ

At minimum, this decision needs before-and-after numbers on IGF-1, fasting glucose, HbA1c, fasting insulin, plus lipids, blood pressure and fluid symptoms