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However, transplanted dopamine neurons have not been able to fully replace the needed amounts of dopamine

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305 The mitochondrial dysfunction associated with aging can impair the ability of cardiac muscle to fulfill ATP demands

For example, instructions for testosterone transdermal products and monitoring vary, but some recommend checking serum testosterone levels 14 days after initiation of therapy with variable recommendations on whether to measure before or after application (given testosterone transdermal offers a smoother pharmacokinetic profile, though consistency is important, measuring prior to or 2 hours after a dose could be reasonable if done consistently)