This extended action increases the risk of side effects seen with prolonged GH elevation: facial flushing, water retention, joint stiffness, and numbness or tingling in hands (carpal tunnel symptoms)
10.1038/nm.4010 [DOI] [PMC free article] [PubMed] [Google Scholar] 27.Zhu Y, Tchkonia T, Pirtskhalava T, Gower AC, Ding H, Giorgadze N, Palmer AK, Ikeno Y, Hubbard GB, Lenburg M, OHara SP, LaRusso NF, Miller JD, et al
GHK-Cu topical dose by indication Face serums / creams: 1 %3 % GHK-Cu, applied once or twice daily (morning and/or evening)
This analysis pooled results from trials of participants with mild cognitive impairment (6 trials) and trials of participants without cognitive impairment (15 trials)