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IL-1 and IL-18, two crucial pro-inflammatory cytokines synthesized during pyroptosis regulation, are implicated in the pathogenesis of inflammatory responses in renal resident cells due to their association with the expression of chemoattractant cytokines and adhesion molecules (119)

A separate human study also found that ingesting 1,000 mg of pomegranate extract, which is rich in UA, prior to a single bout of high-intensity exercise, significantly improved blood flow and vascular diameter in resistance-trained individuals (41)

Potential concerns Some things worth considering: Cancer risk

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