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GLP-1 and Weight Loss Supplements When considering supplements while on GLP-1 medication for weight loss, you might want to focus on evidence-based options that could potentially support your medication rather than competing with it: Amino acids for weight loss May support muscle preservation during calorie restriction Electrolyte complexes May help maintain hydration and fluid balance Vitamin D and calcium Could support muscle function and bone health Introducing Ivims GLP-1 ID Program: Personalized Support for Muscle and Metabolic Health One of the biggest challenges during GLP-1 treatment can be staying on top of your evolving needs, like adjusting your compounded semaglutide or tirzepatide dose, responding to appetite changes, or preventing muscle loss