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The nuclear isoform, in particular, is involved in the process of the chromatin condensation, which occurs in the final steps of spermatogenesis and requires the replacement of the majority of histones, with transition proteins and protamines, essential for the stabilization of DNA and condensation of spermatocytes

Due to the heterogeneity of the studies, a descriptive analysis of the data was performed

RelA/p65 promotes osteoclast differentiation by blocking a RANKL-induced apoptotic JNK pathway in mice

Accumulation of SAH, or a reduction in SAM, thus constrains DNA and histone methylation even when substrate (cytosine or lysine) is available