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Given lactates pivotal role in energy metabolism and signal transduction, systematic investigation of both histone and nonhistone lactylation modifications has become essential

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As a consequence, a loss of lipoic acid-dependent enzymatic activity caused by defects in endogenous lipoic acid synthesis (see Deficiency) cannot be rescued by the provision of exogenous lipoic acid (5)

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Qian J, Morley S, Wilson K, Nava P, Atkinson J, Manor D

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