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Key Considerations for Standard Maintenance Dose: Frequency: Monthly injections are standard for maintenance

Although the combined treatment did not further ameliorate Hb level and reticulocyte count (Supplemental Figure 10, A and B), it produced a greater change in the Hb to RDW ratio, a marker for spherocytes and dense RBCs (Figure 6D), and further decreased annexin-V positivity of RBCs (Figure 6E)

Explored for gut barrier support

The restoration of Akkermansia , a mucin-degrading probiotic critical for mucus layer integrity ( Lactobacillus , known for producing anti-microbial metabolites and modulating immunity, likely supports a healthier microbial environment