glp 1 lymphedema GLP-1 Weight Loss Drugs May Treat After Breast Cancer Tirzepatide as a Potential Disease-Modifying

Sarizkan S, Ozdamar S, Trk G, Cantrk F, Yay A

PI3K/Akt/mTOR and MAPK Pathway Activation IGF-1R engagement activates two primary downstream signalling pathways: the PI3K/Akt/mTOR pathway, primarily responsible for protein synthesis, cell growth, and inhibition of protein breakdown

In terms of respective effects: Ipamorelin therapy increases serum GH, appetite, and body weight

They tried a few tricks: DPP-4-resistant versions: tweaking the GLP-1 molecule so DPP-4 cant see where to cut it Fatty acid tails: causing the GLP-1 to latch onto albumin in your blood, hiding from DPP-4 Encapsulation: wrapping the molecule in protective coatings so it survives longer before being exposed to enzymes These hacks meant the drug could hang out in the bloodstream for hours, or even days, instead of minutes