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Furthermore, treatment with various antidepressants (97), electroconvulsive therapy (ECT) (98) and cognitive behavioral therapy (74) tends to restore GABA level in depressed subjects (99)

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In this paper, we consider the (mis)uses of aqueous p K a values in the organic curriculum and their pedagogical effects, argue for the adoption of p K a values measured in an organic solvent (DMSO) in organic textbooks and reference materials, and explore the thermodynamic origin of the effect of solvent on acidity