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Notably, the IL-6/JAK2/STAT3 pathway exhibits bidirectional regulation: it promotes the accumulation of PUFAs by activating fatty acid synthase (FASN), thereby increasing the risk of ferroptosis, while simultaneously inhibiting CRT exposure to weaken the immunogenicity of ICD (Johnson et al., 2020) (201)

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Tpl2 kinase regulates inflammation but not tumorigenesis in mice

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