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AMPAR removal underlies Abeta-induced synaptic depression and dendritic spine loss

2.4 In vitro cell culture Caco-2 cells (passage #51) were cultured in DMEM (supplemented with 10% FBS) for 3 days on plastic coverslips at the bottom of 1 mL wells in 24-well cluster plates at a density of 1 10 6 cells/mL

Changes relative to baseline lean mass were similar between the groups, and meta-regression analysis indicated that reductions in total body weight were significantly associated with fat mass loss but not with lean mass

This is further supported by the finding that SOD activity is increased during active disease and returns to normal in remission (157).Additionally, the presence of oxidative damage and the inhibition of catalase, an antioxidant enzyme, in CD patients immune cells further underscores oxidative stresss role in the disease (158)