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The clinical gap between a first-step agent and tirzepatide is documented, and a prescriber can reference that gap in a medical necessity letter when step therapy feels clinically inappropriate for a specific patient
13,14 Numerous researches have reported that the function of incretin axis is impaired in T2D or metabolic syndrome, a phenomenon that causes insufficient GLP-1 production, or disrupted GLP-1 action
Louis, United States Zaiyong Zheng, Southwest Medical University, China Updates Copyright 2025 Gong, Li, Shi, Wang, Dai, Chen and Su
539,540,541 Conclusions and prospects The prevalence of UC has been increasing each year, and symptoms such as perennial bloody diarrhea in UC patients have severely affected the quality of life of patients, resulting in UC becoming a serious and pervasive global public health problem
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