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Further details on the experimental protocol and outcomes are available in the Supplementary File 1: Methods and Supplementary File 1: Table S1.2

A 2017 Cochrane review found that over 17% of people who used a patch in conjunction with another type of NRT successfully quit, compared to 14% who used a single form of NRT

This failure of therapeutic action should not be compensated for by increasing the dose in smokers as this might result in the production of toxic, even potentially mutagenic estrogen metabolites - compounds recently associated with a higher risk of breast cancer